Effects of parabiosis of normal with genetically diabetic mice.
نویسندگان
چکیده
COLEMAN, D. L., AND KATHARINE P. HUMMEL. Effects of parabiosis of normal with genetically diabetic mice. Am. J. Physiol. 2 17(5) : 129% 1304. 1969.-Adult diabetic mice (db/db) of the C57BL/Ks strain were joined in parabiosis with normal mice of the same sex. Little, if any, amelioration of the disease was observed in parabiont diabetics and no symptoms of diabetes were observed in the normal parabiont. Instead, the normal partners lost weight, became hypoglycemic, and died of apparent starvation within 50 days after surgery. In contrast, the diabetic partners gained weight rapidly and remained diabetic. The similarity of this response to that observed with normal rats in parabiosis with rats having lesions in the region of the ventromedial nuclei of the hypothalamus is discussed.
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ورودعنوان ژورنال:
- The American journal of physiology
دوره 217 5 شماره
صفحات -
تاریخ انتشار 1969